High Speed Digital Pathology (HSDP) System
20120215 - 20130815
Dr Xiaohua Wu
1) Design documentations for a large FOV and high resolution imaging module, an efficient and robust focus searching algorithm, and a fast and precise auto focusing module 2) A prototype of the large FOV, high resolution imaging module and its performance comparison to a commercial slide digitization system. 3) An efficient and robust focus-searching algorithm for fast auto focusing needed in high throughput slide digitization systems. 4) A prototype of a fast and precise actuation module to realize the developed auto focusing algorithm, and its performance comparison to a commercial slide digitization system. 5) Licensable imaging and focusing technologies including at least two invention/patent disclosures. 6) A large-scale slide digitization and digital pathology diagnosis trial with two hospitals.
Fung To Company Limited [Sponsor] Speed Fair Company Limited [Sponsor]
Digital Pathology is a dynamic, image-based environment that enables the acquisition, management and interpretation of pathology information generated from digitizing a pathology glass slide. Compared to the traditional microscope-based pathology diagnosis with glass slides, digital pathology allows pathologists to view digitized slides remotely through a network without using a microscope. Moreover, pathologists can utilize various imaging analyzing software to do a more quantitative and objective diagnosis for these digitized slides. With such advantages, digital pathology is expected to revolutionize the workflow of pathology department in hospitals and offer the public better and faster diagnostic service. The current technology barriers for general adaption of digital pathology include long digitization time, large image data size and high system cost. The objective of this project is to develop new technologies to speed up the slide digitization process. Our research effort will be focusing on two main directions: (i) a new optical design to increase the field of view of the imaging system to reduce the number of tiles required for each whole slide imaging; (ii) a new mechanical design to increase the response speed of the focusing system to reduce the time spent on achieving good focus for the whole slide.